Background Vascular endothelial cells lost from the bloodvessel endothelium through
necrosis or apoptosis must be replaced. We investigated in a leukaemia model whether …

Vascular endothelial cells are a critical component of the hematopoietic microenvironment
that regulates blood cell production. Recent studies suggest the existence of functional cross …

Despite an important role in vascular development and repair, the origin of endothelial
progenitors remains unknown. Accumulating evidence indicates that cells derived from the …

The mechanisms by which bone marrow (BM)-derived stem cells might contribute to
angiogenesis and the origin of neovascular endothelial cells (ECs) are controversial …

During early embryogenesis, blood vessels and hematopoietic cells arise from a common
precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor …

Tumor growth is dependent in part on “neoangiogenesis.” Functional involvement of bone
marrow (BM)-derived cells in this process has been demonstrated. However, it remains …

It has been proposed that hematopoietic and endothelial cells are derived from a common
cell, the hemangioblast. In this study, we demonstrate that a subset of CD34+ cells have the …

1. Takahashi, T. et al. Ischemia-and cytokine-induced mobilization of bone-marrow derived
endothelial progenitor cells for neovascularization. Nature Med. 5, 434–438 (1999). 2 …

Recent evidence indicates that bone marrow is a source of endothelial progenitor cells that
are mobilized into the peripheral blood in response to cytokines or tissue injury. Previously …

Seven patients were included in this study, all of whom were men with atherosclerotic
occlusion. The mean age was 65· 3 years (SD 8· 0; range 60–74), and the mean bodyweight …