[HTML][HTML] SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome
In this study, we observed worsening metabolic crosstalk in mouse models with concomitant
metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and …
metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and …
[HTML][HTML] AHR is a master regulator of diverse pathways in endogenous metabolism
JC Granados, K Falah, I Koo, EW Morgan… - Scientific reports, 2022 - nature.com
The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification,
development, immune response, chronic kidney disease and other syndromes. It regulates …
development, immune response, chronic kidney disease and other syndromes. It regulates …
[HTML][HTML] Myocardial metabolic alterations in mice with diet-induced atherosclerosis: linking sulfur amino acid and lipid metabolism
Atherosclerosis is a leading cause of cardiovascular disease (CVD), but the effect of diet on
the atherosclerotic heart's metabolism is unclear. We used an integrated metabolomics and …
the atherosclerotic heart's metabolism is unclear. We used an integrated metabolomics and …
Hepatic mitochondrial SAB deletion or knockdown alleviates diet‐induced metabolic syndrome, steatohepatitis, and hepatic fibrosis
S Win, RWM Min, J Zhang, G Kanel, B Wanken… - …, 2021 - Wiley Online Library
Background and Aims The hepatic mitogen‐activated protein kinase (MAPK) cascade
leading to c‐Jun N‐terminal kinase (JNK) activation has been implicated in the …
leading to c‐Jun N‐terminal kinase (JNK) activation has been implicated in the …
Homocysteine levels and outside‐in insulin signaling in human and mouse tissues
Hyperhomocysteinemia (HHcy) and insulin resistance both are associated with the
atherosclerotic cardiovascular disease. However, the effect and mechanism of …
atherosclerotic cardiovascular disease. However, the effect and mechanism of …
Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production
Chemical compounds have recently been introduced as alternative and non‐integrating
inducers of pluripotent stem cell fate. However, chemical reprogramming is hampered by …
inducers of pluripotent stem cell fate. However, chemical reprogramming is hampered by …
Hydrogen sulfide and glucose homeostasis: a tale of sweet and the stink
A Untereiner, L Wu - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Among many endogenous mediators, the gasotransmitter hydrogen sulfide
(H2S) plays an important role in the regulation of glucose homeostasis. In this article we …
(H2S) plays an important role in the regulation of glucose homeostasis. In this article we …
[HTML][HTML] Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …
Redox signaling in inherited diseases of metabolism
DW Jacobsen, L Hannibal - Current Opinion in Physiology, 2019 - Elsevier
Highlights•Redox signaling modulates metabolism from molecules to organs.•Molecular
specificity depends on permeability and reactivity of reactive species and target.•Cellular …
specificity depends on permeability and reactivity of reactive species and target.•Cellular …
[HTML][HTML] H2S protects from oxidative stress-driven ACE2 expression and cardiac aging
Abstract Cystathionine gamma-lyase (CSE)-derived hydrogen sulfide (H2S) plays an
essential role in preserving cardiac functions. Angiotensin-converting enzyme 2 (ACE2) acts …
essential role in preserving cardiac functions. Angiotensin-converting enzyme 2 (ACE2) acts …