This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

Understanding the organisation and role of the extracellular matrix (ECM) in islets of
Langerhans is critical for maintaining pancreatic β‐cells, and to recognise and revert the …

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

Clinical treatment of diabetic patients by islet transplantation faces various complications. At
present, in vitro expansion of islets occurs at the cost of their essential features, which are …

Abstract Purposes of Review Extracellular matrix (ECM) components modulate the
interaction between pancreatic islet cells. During the islet isolation prior to transplantation as …

Abstract Type 1 diabetes (T1D) results from progressive immune cell-mediated destruction
of pancreatic β cells. As immune cells migrate into the islets, they pass through the …

The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …