Synthetic biology strategies for microbial biosynthesis of plant natural products

A Cravens, J Payne, CD Smolke - Nature communications, 2019 - nature.com
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Engineering biosynthetic enzymes for industrial natural product synthesis

S Galanie, D Entwistle, J Lalonde - Natural Product Reports, 2020 - pubs.rsc.org
Covering: 2000 to 2020 Natural products and their derivatives are commercially important
medicines, agrochemicals, flavors, fragrances, and food ingredients. Industrial strategies to …

Metabolic engineering for plant natural product biosynthesis in microbes

JA Chemler, MAG Koffas - Current opinion in biotechnology, 2008 - Elsevier
Plant natural products (NPs) not only serve many functions in an organism's survivability but
also demonstrate important pharmacological activities. Isolation of NPs from native sources …

[PDF][PDF] Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Engineering plant metabolism into microbes: from systems biology to synthetic biology

P Xu, N Bhan, MAG Koffas - Current opinion in biotechnology, 2013 - Elsevier
Plant metabolism represents an enormous repository of compounds that are of
pharmaceutical and biotechnological importance. Engineering plant metabolism into …

Construction and optimization of synthetic pathways in metabolic engineering

D Na, TY Kim, SY Lee - Current opinion in microbiology, 2010 - Elsevier
Metabolic engineering has enabled us to develop strains suitable for their use as microbial
factories of chemicals and materials from renewable sources. It has recently become more …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

Microbial chassis development for natural product biosynthesis

X Xu, Y Liu, G Du, R Ledesma-Amaro, L Liu - Trends in biotechnology, 2020 - cell.com
Engineering microbial cells to efficiently synthesize high-value-added natural products has
received increasing attention in recent years. In this review, we describe the pipeline to build …

Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production

X Liu, W Ding, H Jiang - Microbial cell factories, 2017 - Springer
Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals,
seasonings, pigments, etc., with a huge commercial value on the global market. However …

De novo biosynthetic pathways: rational design of microbial chemical factories

KLJ Prather, CH Martin - Current opinion in biotechnology, 2008 - Elsevier
Increasing interest in the production of organic compounds from non-petroleum-derived
feedstocks, especially biomass, is a significant driver for the construction of new …