In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Tumor cells often show a decrease in cell–cell and/or cell–matrix adhesion. An increasing
body of evidence indicates that this reduction in cell adhesion correlates with tumor invasion …

Approximately 90% of all cancer deaths arise from metastasis formation. Hence,
understanding the molecular mechanisms underlying tumor progression, local invasion, and …

The signalling activity of cell adhesion molecules (CAMs) such as cadherins,
immunoglobulin-like CAMs or integrins has long been considered to be a direct …

Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular
matrix interactions of cancer. Cancer progression is a multi-step process in which some …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

Progression to tumour malignancy involves changes in a tumour cell's capabilities to adhere
and communicate with neighboring cells and with its extracellular environment. Correlation …

Morphogenesis is the process by which cells become organized into distinctive structures
and histological patterns in the tissues and organs of the body. Cellular morphogenetic …

J. Clin. Invest. 109: 987–991 (2002). DOI: 10.1172/JCI200215429. repress its promoter.
These include snail, E12/E47, and SIP1, which bind to the CDH1 promoter, inhibit E-cad …

Receptors tyrosine kinases (RTKs) and cell adhesion molecules (CAMs) present on the cell
surface sense the surrounding environment and influence the fate of cells. For a long time, it …