RNA-Binding Proteins in Cardiomyopathies
DL Shi - Journal of Cardiovascular Development and Disease, 2024 - mdpi.com
The post-transcriptional regulation of gene expression plays an important role in heart
development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding …
development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding …
RNA-binding proteins in cardiovascular biology and disease: The beat goes on
Cardiac development and function are becoming increasingly well understood from different
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …
Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease
RG de Bruin, TJ Rabelink… - European heart …, 2017 - academic.oup.com
The cardiovascular system comprises multiple cell types that possess the capacity to
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …
RNA-binding proteins as critical post-transcriptional regulators of cardiac regeneration
DL Shi - International Journal of Molecular Sciences, 2023 - mdpi.com
Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult
mammalian heart has very limited regenerative capacity. However, the heart from early …
mammalian heart has very limited regenerative capacity. However, the heart from early …
In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms
Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …
underlying molecular mechanisms and the extent to which the fetal program switch occurs …
RNA binding proteins as mediators of pathological cardiac remodeling
RNA binding proteins (RBPs) play a central in the post-transcriptional regulation of gene
expression, which can account for up to 50% of all variations in protein expression within a …
expression, which can account for up to 50% of all variations in protein expression within a …
RNA-binding proteins in heart development
RNA-binding proteins (RBPs) are key players of posttranscriptional regulation occurring
during normal tissue development. All tissues examined thus far have revealed the …
during normal tissue development. All tissues examined thus far have revealed the …
[HTML][HTML] The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases
L Lin, J Chu, S An, X Liu, R Tan - Biomolecules, 2024 - mdpi.com
RNA-binding proteins (RBPs) have pivotal roles in cardiovascular biology, influencing
various molecular mechanisms underlying cardiovascular diseases (CVDs). This review …
various molecular mechanisms underlying cardiovascular diseases (CVDs). This review …
A roadmap for fixing the heart: RNA regulatory networks in cardiac disease
R Tang, T Long, KO Lui, Y Chen, ZP Huang - Molecular Therapy-Nucleic …, 2020 - cell.com
With the continuous development of RNA biology and massive genome-wide transcriptome
analysis, more and more RNA molecules and their functions have been explored in the last …
analysis, more and more RNA molecules and their functions have been explored in the last …
The cardiomyocyte RNA-binding proteome: links to intermediary metabolism and heart disease
RNA functions through the dynamic formation of complexes with RNA-binding proteins
(RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL …
(RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL …