Identification of hepatocellular carcinoma related genes with k-th shortest paths in a protein–protein interaction network

M Jiang, Y Chen, Y Zhang, L Chen, N Zhang… - Molecular …, 2013 - pubs.rsc.org
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide and
one of the deadliest cancers in Asia. But at present, effective targets for HCC clinical therapy …

Applying NGS data to find evolutionary network biomarkers from the early and late stages of hepatocellular carcinoma

YH Wong, CC Wu, CL Lin, TS Chen… - BioMed Research …, 2015 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a major liver tumor (~ 80%), besides hepatoblastomas,
angiosarcomas, and cholangiocarcinomas. In this study, we used a systems biology …

Identification of Lung‐Cancer‐Related Genes with the Shortest Path Approach in a Protein‐Protein Interaction Network

BQ Li, J You, L Chen, J Zhang, N Zhang… - BioMed research …, 2013 - Wiley Online Library
Lung cancer is one of the leading causes of cancer mortality worldwide. The main types of
lung cancer are small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). In …

Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network

BQ Li, T Huang, L Liu, YD Cai, KC Chou - PloS one, 2012 - journals.plos.org
One of the most important and challenging problems in biomedicine and genomics is how to
identify the disease genes. In this study, we developed a computational method to identify …

Core and specific network markers of carcinogenesis from multiple cancer samples

YH Wong, RH Chen, BS Chen - Journal of theoretical biology, 2014 - Elsevier
Cancer is the leading cause of death worldwide and is generally caused by mutations in
multiple proteins or the dysregulation of pathways. Understanding the causes and the …

OPMSP: A computational method integrating protein interaction and sequence information for the identification of novel putative oncogenes

L Chen, B Wang, SP Wang, J Yang, J Hu… - Protein and Peptide …, 2016 - ingentaconnect.com
Oncogenes are genes that have the potential to cause cancer. Oncogene research can
provide insight into the occurrence and development of cancer, thereby helping to prevent …

Identification of target genes in cancer diseases using protein–protein interaction networks

A Amala, IA Emerson - Network Modeling Analysis in Health Informatics …, 2019 - Springer
Cancer is a disease that is characterized by uncontrolled cell growth with the ability to
penetrate or develop to the other parts of the body. Various studies have shown the …

Hepatitis C virus protein interaction network analysis based on hepatocellular carcinoma

Y Han, J Niu, D Wang, Y Li - PLoS One, 2016 - journals.plos.org
Epidemiological studies have validated the association between hepatitis C virus (HCV)
infection and hepatocellular carcinoma (HCC). An increasing number of studies show that …

[HTML][HTML] Design protein-protein interaction network and protein-drug interaction network for common cancer diseases: A bioinformatics approach

MR Hasan, BK Paul, K Ahmed, T Bhuyian - Informatics in Medicine …, 2020 - Elsevier
Background In terms of genomics, bioinformatics conceptualizes biological processes and
utilizes computer science to generate knowledge from biological data. Bioinformatics is …

Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (E ncyclopedia of H epatocellular C arcinoma genes O nline)

CN Hsu, JM Lai, CH Liu, HH Tseng, CY Lin, KT Lin… - BMC …, 2007 - Springer
Background The significant advances in microarray and proteomics analyses have resulted
in an exponential increase in potential new targets and have promised to shed light on the …