Background: Aberrant promoter hypermethylation has been recognized in human breast
carcinogenesis as a frequent molecular alteration associated with the loss of expression of a …

Gastric cancer (GC) is the fourth most prevalant cancer and the second leading cause of
cancer-related mortality worldwide. As in other cancers gastric carcinogenesis is …

Background The E-cadherin gene (CDH1) maps, at chromosome 16q22. 1, a region often
associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is …

The E-cadherin gene (CDH1) is associated with poor prognosis and metastasis in patients
with breast cancer, and methylation of its promoter is correlated with decreased gene …

Breast cancer is the most common cancer in women around the world, and novel prognosis
strategies is needed to control more accurate and effective of this malignant disease. Among …

Background: E-cadherin (CDH1) plays an important role in cell–cell adhesion of epithelial
tissues. Loss of E-cadherin expression can lead to loss of tissue integrity, metastasis, and …

Simple Summary Genes can be inactivated by specific modifications of DNA bases, most
often by adding a methyl group to the DNA base cytosine if it is followed by guanosine (CG …

Background The down-regulation of E-cadherin gene (CDH1) expression has been
regarded as an important event in cancer invasion and metastasis. However, the association …

Aim: This study was performed to evaluate the correlation between CDH1 promoter
methylation and cervical cancer. Methods: Trial sequential analysis was conducted to …

Background Hypermethylation is studied as a new, relevant mechanism for silencing tumor
suppressor genes. It is a potentially reversible epigenetic change and it is the target of novel …