Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy

X Zhu, W Yun, X Sun, F Qiu, L Zhao, Y Guo - Pharmacogenomics, 2014 - Taylor & Francis
Aim: The present study aimed to evaluate the effects of SNPs of major transporter and
metabolizing enzyme genes on carbamazepine (CBZ) metabolism in Chinese patients with …
被引用次数：46 相关文章 所有 6 个版本

Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in …

P Wang, T Yin, HY Ma, DQ Liu, YH Sheng, C Wang… - Epilepsy research, 2015 - Elsevier
Objective To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5
(CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic …
被引用次数：47 相关文章 所有 5 个版本
[HTML] nih.gov

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy

YG Puranik, AK Birnbaum, SE Marino… - …, 2013 - Taylor & Francis
Aim: The aim of this study was to evaluate the association of genetic variants in the major
genes involved in carbamazepine (CBZ) metabolism and transport with its pharmacokinetics …
被引用次数：131 相关文章 所有 12 个版本

Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy

W Yun, F Zhang, C Hu, X Luo, P Xue, J Wang, Y Ge… - Epilepsy research, 2013 - Elsevier
The pharmacokinetics and pharmacodynamics of carbamazepine (CBZ) vary widely among
patients with epilepsy. In this study, we sought to investigate the effects of genetic …
被引用次数：38 相关文章 所有 6 个版本

Effects of EPHX1 and CYP3A4*22 genetic polymorphisms on carbamazepine metabolism and drug response among Tunisian epileptic patients

C Chbili, N Fathallah, A Laouani, M Nouira… - Journal of …, 2016 - Taylor & Francis
The aim of this study was to evaluate the impact of polymorphisms in the EPHX1 (c. 416A>
G, c. 337T> C) and CYP3A4* 22 genes involved in carbamazepine (CBZ) metabolism and …
被引用次数：33 相关文章 所有 3 个版本
[PDF] tandfonline.com

Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients

A Caruso, C Bellia, A Pivetti, L Agnello… - Pharmacogenomics …, 2014 - Taylor & Francis
Background The aim of this study was to investigate the effect of two genetic polymorphisms
in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T> C and 416A> G …
被引用次数：39 相关文章 所有 16 个版本
[PDF] ualberta.ca

First analysis of the association between CYP3A4/5, ABCB1 genetic polymorphisms and oxcarbazepine metabolism and transport in chinese epileptic patients with …

W Ping, Y Tao, M HongYing… - … of pharmacy & …, 2015 - journals.library.ualberta.ca
Purpose: Oxcarbazepine (OXC) is widely used in anti-epileptic treatment. Cytochrome P450
3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5), and ATP-binding cassette sub-family B …
被引用次数：12 相关文章 所有 3 个版本

Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy

H Meng, G Guo, J Ren, H Zhou, Y Ge, Y Guo - Epilepsy & Behavior, 2011 - Elsevier
P-glycoprotein may play a role in drug resistance in epilepsy by limiting gastrointestinal
absorption and brain access of antiepileptic drugs (AEDs). We sought to investigate the …
被引用次数：80 相关文章 所有 7 个版本
[HTML] lww.com

[HTML][HTML] Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients

Q Lu, YT Huang, Y Shu, P Xu, DX Xiang, Q Qu, J Qu - Medicine, 2018 - journals.lww.com
Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual
variability in serum concentrations. Previous studies found that CYP3A5* 3 (rs776746) …
被引用次数：15 相关文章 所有 5 个版本
[PDF] neurologyasia.org

[PDF][PDF] Association study of CYP3A5 genetic polymorphism with serum concentrations of carbamazepine in Chinese epilepsy patients

H Meng, J Ren, Y Lv, W Lin, Y Guo - Neurology Asia, 2011 - neurologyasia.org
Objective: To investigate the association between the CYP3A5 genetic polymorphism and
the serum concentrations of carbamazepine (CBZ), to provide guidance for individualized …
被引用次数：24 相关文章 所有 8 个版本