Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and …
A Vora, N Goulden, C Mitchell, J Hancock… - The lancet …, 2014 - thelancet.com
Background No randomised study has shown whether stratification of treatment by minimal
residual disease (MRD) response improves outcome in children and young people with …
residual disease (MRD) response improves outcome in children and young people with …
Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised …
A Vora, N Goulden, R Wade, C Mitchell… - The lancet …, 2013 - thelancet.com
Background Minimal residual disease (MRD) is the most sensitive and specific predictor of
relapse risk in children with acute lymphoblastic leukaemia (ALL) during remission. We …
relapse risk in children with acute lymphoblastic leukaemia (ALL) during remission. We …
Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective …
CH Pui, D Pei, E Coustan-Smith, S Jeha… - The lancet …, 2015 - thelancet.com
Background The level of minimal residual disease during remission induction is the most
important prognostic indicator in patients with acute lymphoblastic leukaemia (ALL). We …
important prognostic indicator in patients with acute lymphoblastic leukaemia (ALL). We …
Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: study ALL10 from the …
R Pieters, H de Groot-Kruseman… - Journal of clinical …, 2016 - ascopubs.org
Purpose Outcome of childhood acute lymphoblastic leukemia (ALL) improved greatly by
intensifying chemotherapy for all patients. Minimal residual disease (MRD) levels during the …
intensifying chemotherapy for all patients. Minimal residual disease (MRD) levels during the …
Clinical impact of minimal residual disease in children with different subtypes of acute lymphoblastic leukemia treated with response-adapted therapy
CH Pui, D Pei, SC Raimondi, E Coustan-Smith, S Jeha… - Leukemia, 2017 - nature.com
To determine the clinical significance of minimal residual disease (MRD) in patients with
prognostically relevant subtypes of childhood acute lymphoblastic leukemia (ALL), we …
prognostically relevant subtypes of childhood acute lymphoblastic leukemia (ALL), we …
Minimal residual disease–guided treatment deintensification for children with acute lymphoblastic leukemia: results from the Malaysia-Singapore acute lymphoblastic …
Purpose To improve treatment outcome for childhood acute lymphoblastic leukemia (ALL),
we designed the Malaysia-Singapore ALL 2003 study with treatment stratification based on …
we designed the Malaysia-Singapore ALL 2003 study with treatment stratification based on …
Minimal residual disease is an important predictive factor of outcome in children with relapsed 'high-risk'acute lymphoblastic leukemia
M Paganin, M Zecca, G Fabbri, K Polato, A Biondi… - Leukemia, 2008 - nature.com
The aim of the study was to analyze the impact of minimal residual disease (MRD) after
reinduction therapy on the outcome of children with relapsed 'high-risk'acute lymphoblastic …
reinduction therapy on the outcome of children with relapsed 'high-risk'acute lymphoblastic …
Association of minimal residual disease with clinical outcome in pediatric and adult acute lymphoblastic leukemia: a meta-analysis
Importance Minimal residual disease (MRD) refers to the presence of disease in cases
deemed to be in complete remission by conventional pathologic analysis. Assessing the …
deemed to be in complete remission by conventional pathologic analysis. Assessing the …
Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment
C Eckert, N Hagedorn, L Sramkova, G Mann… - Leukemia, 2015 - nature.com
The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is
poor. Here, we assessed the prognostic importance of response during induction and …
poor. Here, we assessed the prognostic importance of response during induction and …
Use of minimal residual disease assessment to redefine induction failure in pediatric acute lymphoblastic leukemia
D O'Connor, AV Moorman, R Wade… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual
disease (MRD) assessment in the identification and stratification of induction failure in …
disease (MRD) assessment in the identification and stratification of induction failure in …