Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention

S Kaufhold, B Bonavida - Journal of Experimental & Clinical Cancer …, 2014 - Springer
Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

SNAIL1: linking tumor metastasis to immune evasion

X Tang, X Sui, L Weng, Y Liu - Frontiers in immunology, 2021 - frontiersin.org
The transcription factor Snail1, a key inducer of epithelial-mesenchymal transition (EMT),
plays a critical role in tumor metastasis. Its stability is strictly controlled by multiple …

Snail1-dependent activation of cancer-associated fibroblast controls epithelial tumor cell invasion and metastasis

L Alba-Castellón, R Olivera-Salguero, A Mestre-Farrera… - Cancer research, 2016 - AACR
Snail1 transcriptional factor is essential for triggering epithelial-to-mesenchymal transition
(EMT) and inducing tumor cell invasion. We report here an EMT-independent action of …

Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines

D Olmeda, A Montes, G Moreno-Bueno, JM Flores… - Oncogene, 2008 - nature.com
Abstract Snai1 (Snail) and Snai2 (Slug), the two main members of Snail family factors, are
important mediators of epithelial-mesenchymal transitions and involved in tumor …

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

NH Kim, HS Kim, XY Li, I Lee, HS Choi, SE Kang… - Journal of Cell …, 2011 - rupress.org
Snail1 is a zinc finger transcriptional repressor whose pathological expression has been
linked to cancer cell epithelial–mesenchymal transition (EMT) programs and the induction of …

SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells

D Olmeda, G Moreno-Bueno, JM Flores, A Fabra… - Cancer research, 2007 - AACR
The transcription factor, SNAI1 (Snail), has recently been proposed as an important mediator
of tumor invasion because of its role in E-cadherin down-regulation and induction of …

Transient SNAIL1 expression is necessary for metastatic competence in breast cancer

HD Tran, K Luitel, M Kim, K Zhang, GD Longmore… - Cancer research, 2014 - AACR
SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of
human breast tumor transcriptomes and experiments using cancer cell lines and xenografts …

Molecular regulation of Snai2 in development and disease

W Zhou, KM Gross, C Kuperwasser - Journal of cell science, 2019 - journals.biologists.com
The transcription factor Snai2, encoded by the SNAI2 gene, is an evolutionarily conserved
C2H2 zinc finger protein that orchestrates biological processes critical to tissue development …

Effect of modulation of epithelial‑mesenchymal transition regulators Snail1 and Snail2 on cancer cell radiosensitivity by targeting of the cell cycle, cell apoptosis and …

G Assani, Y Zhou - Oncology letters, 2019 - spandidos-publications.com
Cancer is one of the leading causes of cancer‑associated mortality worldwide. Several
strategies of treatment, including radiotherapy, have been developed and used to treat this …

Snail: more than EMT

Y Wu, BP Zhou - Cell adhesion & migration, 2010 - Taylor & Francis
Snail has moved into the fast lane of development and cancer biology with the epithelial-
mesenchymal transition (EMT) emerging as one of the hottest topics in medical science …