Obesity mediates most of its direct medical sequelae through the development of insulin
resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways …

The metabolic syndrome affects more than a third of the US population, predisposing to the
development of type 2 diabetes and cardiovascular disease. The 2009 consensus statement …

Obesity is a major health risk factor, and obesity-induced morbidity and complications
account for huge costs for affected individuals, families, healthcare systems, and society at …

Dementia is a devastating disease associated with aging. Alzheimer's disease is the most
common form of dementia, followed by vascular dementia. In addition to clinically diagnosed …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …

Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic
factors contribute at what has canonically been considered a centrally mediated process …

Aim Insulin has a well-established role in cognition, neuronal detoxification and synaptic
plasticity. Insulin transduction affect neurotransmitter functions, influence bioenergetics and …

Insulin exists in the central nervous system, where it executes two important functions in the
hypothalamus: the suppression of food intake and the improvement of glucose metabolism …

The comprehensive anabolic effects of insulin throughout the body, in addition to the control
of glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation …