P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …

Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by various cellular
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …

A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …

Background An accumulating body of evidence is consistent with the hypothesis that
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD is
characterized by progressive neuronal degeneration that is accompanied by the formation of …

Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …