In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Age-related decline in female fertility is a common feature that occurs in the fourth decade of
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …

Melatonin is a well‐characterized antioxidant that has been successfully used to protect
oocytes from reactive oxygen species during in vitro maturation (IVM), resulting in improved …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Aims Previous reports have demonstrated that melatonin exists in multiple extrapineal sites,
and higher amounts of melatonin are present in human follicular fluid than in serum, which …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

Background Melatonin, as a free radical scavenger exhibiting genomic actions, regulates
the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome …