Lippincott Continuing Medical Education Institute, Inc., designates this enduring material for
a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit …

Purpose Despite the availability of a wide variety of analgesics, many patients with chronic
pain often experience suboptimal pain relief in part related to the absence of any medication …

Abstract Purpose of Review The purpose of this review is to evaluate and explain our current
understanding of the clinical use of low-dose naltrexone in the treatment of chronic pain …

Methods, Supplemental Digital Content). A 2020 systematic review of six RCTs (N5961)
compared the effectiveness of low-dose naltrexone (LDN) with a dosing range of 1.5 to 5 mg …

Naltrexone is a mu-opioid receptor antagonist increasingly used as an analgesic for chronic
pain at low doses. This retrospective, observational cohort study was conducted at an …

Chronic inflammatory diseases are complex to treat and have an impact on a large number
of patients. Due to the difficulty of treating these diseases and the great impact on quality of …

The Use of Low-Dose Naltrexone for Chronic Pain Page 1 A SCP .C OM/JOURNAL 43 NEW
PERSPECTIVES The use of low-dose naltrexone for the treatment of chronic pain is novel …

Studies have demonstrated the benefits of LDN for various pain indications. This review
describes the utilization of and response to LDN in patients with chronic pain within the …

Current pharmacologic treatments may provide limited analgesia in fibromyalgia and other
chronic pain disorders. Low-dose naltrexone (LDN) has emerged as a potential analgesic …

Over the past decade there has been significant advancement in understanding the
multitude of ways naltrexone interacts with human physiology. The two main theories …