The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

The topoisomerase enzymes are essential for DNA metabolism, where they act to adjust the
number of supercoils in DNA, a key requirement in the cellular processes of transcription …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

DNA topoisomerases are nuclear enzymes that play essential roles in DNA metabolic
processes. These enzymes carry out strand passage to maintain appropriate DNA structure …

Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …

DNA topoisomerases are essential enzymes that regulate the conformational changes in
DNA topology by catalysing the concerted breakage and rejoining of DNA strands during …

DNA topoisomerases comprise a major aspect of basic cellular biology and are molecular
targets for a variety of drugs like antibiotics, antibacterials and anticancer drugs. They act by …

The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …

A number of clinically important anticancer drugs have recently been shown to kill tumor
cells by affecting DNA topoisomerases. Topoisomerases are essential nuclear enzymes that …

DNA topoisomerases play important roles in basic cellular biology. Recently they have been
identified as the molecular targets of a variety of pharmaceutical agents. Some of the drugs …