Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway

L Duan - 2024 - researchsquare.com
Psychological stress can lead to gut dysbiosis, yet the precise mechanisms underlying the
transfer of stress signals from the brain to the gut remain elusive. Here we describe a new …

[HTML][HTML] Understanding the connection between gut homeostasis and psychological stress

H Zhang, Z Wang, G Wang, X Song, Y Qian, Z Liao… - The Journal of …, 2023 - Elsevier
Long-term exposure to adverse life events that provoke acute or chronic psychological
stress (hereinafter “stress”) can negatively affect physical health and even increase …

Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like …

M Vicario, C Alonso, M Guilarte, J Serra… - …, 2012 - Elsevier
The association between psychological and environmental stress with functional
gastrointestinal disorders, especially irritable bowel syndrome (IBS), is well established …

[PDF][PDF] Altered Gut Microbiome and Inflammasome Activation in Corticotropin Releasing Hormone (CRH)-Deficient Mice Indicate a Novel Role for the Stress Hormone …

AP Apostolou, P Giannogonas… - …, 2017 - researchgate.net
Background & aims: Corticotropin Releasing Hormone (CRH) is the major mediator of the
adaptive response to stressors in mammals. Studies from several groups including ours …

IDDF2021-ABS-0074 Gut microbial metabolite of tryptophan retards intestinal stem cell maintenance under psychological stress in mice

X Zheng, Y Liu - 2021 - gut.bmj.com
Background Psychosocial stress has a negative impact on gastrointestinal homeostasis in
part via brain-gut microbiota mechanisms that are poorly understood. Despite the significant …

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes

JM Allen, AR Mackos, RM Jaggers, PC Brewster… - bioRxiv, 2021 - biorxiv.org
Psychological stress alters the gut microbiota and predisposes individuals to increased risk
for enteric infections and chronic bowel conditions. Intestinal epithelial cells (IECs) are …

Does stress induce bowel dysfunction?

YM Chang, M El-Zaatari, JY Kao - Expert review of …, 2014 - Taylor & Francis
Psychological stress is known to induce somatic symptoms. Classically, many gut
physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis …

Microbial metabolite: a link between psychological stress and epithelial disturbance

D Reed - Gastroenterology, 2024 - Elsevier
A recent study by Wei, Liu, Hou et al the investigated how psychological stress conveys
epithelial disturbance. Using chronic restraint stress (CRS) to model psychological stress in …

[HTML][HTML] Gastrointestinal (non-systemic) antibiotic rifaximin differentially affects chronic stress-induced changes in colon microbiome and gut permeability without effect …

D Kuti, Z Winkler, K Horváth, B Juhász… - Brain, Behavior, and …, 2020 - Elsevier
Chronic stress is often accompanied by gastrointestinal symptoms, which might be due to
stress-induced shift of gut microbiome to pathogenic bacteria. It has been hypothesized that …

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes

JM Allen, AR Mackos, RM Jaggers, PC Brewster… - Gut …, 2022 - Taylor & Francis
Psychological stress alters the gut microbiota and predisposes individuals to increased risk
for enteric infections and chronic bowel conditions. Intestinal epithelial cells (IECs) are …