Intercellular crosstalk among various liver cells plays an important role in liver fibrosis,
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. It is a critical pre-stage condition of severe hepatopathy, characterized by excessive …

Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver
injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially …

Chronic liver diseases are attributed to liver injury. Development of fibrosis from chronic liver
diseases is a dynamic process that involves multiple molecular and cellular processes. As …

Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

Hepatic stellate cells (HSCs) are located in the space of Disse, between liver sinusoidal
endothelia cells (LSECs) and hepatocytes. They have surprised and excited hepatologists …

Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a
worldwide health concern. Insufficient treatment of chronic liver injury leads to fibrosis …

Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of
different etiologies. Previous studies have hypothesized that the activation of hepatic stellate …

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …