Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven
members, widely expressed in mammals. SIRTs mainly participate in metabolic …

The past few decades have witnessed a furious attention of scientific community toward
identifying novel molecular factors and targets that could be exploited for drug development …

The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …

The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and
SIRT5) localise specifically within mitochondria and preserve mitochondrial function and …

Significance: Maintenance of metabolic homeostasis is critical for cellular and organismal
health. Proper regulation of mitochondrial functions represents a crucial element of overall …

Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial
sirtuins,(Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This …

Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent
type III histone deacetylases, are produced by cells to support in the defense against chronic …

Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the
cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria …

Abstract Sirtuin-3 (Sirt3), a sub-family member of the nicotinamide adenine dinucleotide-
dependent histone deacetylases, has been reported to be involved in mitochondrial …

The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …