Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

Background Loss-of-function mutations in GRN cause frontotemporal lobar degeneration
(FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

Abstract Introduction The Advancing Research and Treatment for Frontotemporal Lobar
Degeneration (ARTFL) and Longitudinal Evaluation of Familial Frontotemporal Dementia …

Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom
onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is …

Importance A significant portion of frontotemporal lobar degeneration (FTLD) is due to
inherited gene mutations, and we are unaware of a large sequential series that includes a …

Methods We investigated the frequencies and mutations in neurodegenerative disease
genes in 121 consecutive FTD subjects using an unbiased, combined sequencing …

Frontotemporal dementia (FTD) is the second most common young-onset dementia and is
clinically characterised by progressive behavioural change, executive dysfunction and …

Importance Behavioral disturbances are core features of frontotemporal dementia (FTD);
however, symptom progression across the course of disease is not well characterized in …