Since 2011, phenotypic screening has been a trend in the pharmaceutical industry as well
as in academia. This renaissance was triggered by analyses that suggested that phenotypic …

The research community has witnessed a resurgence over the last several years in the
enthusiasm for phenotypic screening as an approach for small-molecule discovery. In the …

Phenotypic screening for drug discovery is making a comeback, but not everybody is
embracing it. Some pharmas, such as Novartis and GSK, are placing a bet on phenotypic …

Phenotypic screening is making a comeback. Rather than just searching for drug leads on
the basis of a preconceived notion that a particular target is important, this means that drug …

Cumulative scientific and technological advances over the past two centuries have
transformed drug discovery from a largely serendipitous process into the high tech pipelines …

Phenotypic drug discovery approaches can positively affect the translation of preclinical
findings to patients. However, not all phenotypic assays are created equal. A critical …

In this article, we discuss the merits of both target-based and phenotypic screening
strategies to find starting points for drug discovery projects in neglected tropical disease …

The level of mechanistic understanding required for drug discovery is a central feature of
most strategies. However, an understanding of mechanism is not required for regulatory …

The pharmaceutical industry (Pharma) is currently facing unprecedented challenges. In
addition to strategic patent expirations, the rate of drug launches has been essentially …

Although most screening for new drug leads is being directed at known or emerging
molecular targets, there has been a renaissance in screening based on changes in cell or …