The role of iron and siderophores in infection, and the development of siderophore antibiotics
MGP Page - Clinical Infectious Diseases, 2019 - academic.oup.com
Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …
Siderophore–antibiotic conjugates: exploiting iron uptake to deliver drugs into bacteria
IJ Schalk - Clinical Microbiology and Infection, 2018 - clinicalmicrobiologyandinfection …
The growing problem of bacterial antibiotic resistance makes the discovery and
development of new antibiotics increasingly urgent. Otherwise, we will be forced back to a …
development of new antibiotics increasingly urgent. Otherwise, we will be forced back to a …
Cefiderocol: a novel siderophore cephalosporin
JJ Choi, MW McCarthy - Expert opinion on investigational drugs, 2018 - Taylor & Francis
Introduction: The emergence of multidrug-resistant bacterial pathogens has led to a global
public health emergency and novel therapeutic options and drug-delivery systems are …
public health emergency and novel therapeutic options and drug-delivery systems are …
Cefiderocol: discovery, chemistry, and in vivo profiles of a novel siderophore cephalosporin
T Sato, K Yamawaki - Clinical Infectious Diseases, 2019 - academic.oup.com
The emergence of antimicrobial resistance is a significant public health issue worldwide,
particularly for healthcare-associated infections caused by carbapenem-resistant gram …
particularly for healthcare-associated infections caused by carbapenem-resistant gram …
Siderophore–antibiotic conjugate design: New drugs for bad bugs?
KH Negash, JKS Norris, JT Hodgkinson - Molecules, 2019 - mdpi.com
Antibiotic resistance is a global health concern and a current threat to modern medicine and
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …
Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
Iron uptake mechanisms of pathogenic bacteria
KG Wooldridge, PH Williams - FEMS microbiology reviews, 1993 - academic.oup.com
Most of the iron in a mammalian body is complexed with various proteins. Moreover, in
response to infection, iron availability is reduced in both extracellular and intracellular …
response to infection, iron availability is reduced in both extracellular and intracellular …
In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria
A Ito, T Sato, M Ota, M Takemura… - Antimicrobial agents …, 2018 - Am Soc Microbiol
ABSTRACT Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …
Siderophore conjugates to combat antibiotic-resistant bacteria
Antimicrobial resistance (AMR) is a global threat to society due to the increasing emergence
of multi-drug resistant bacteria that are not susceptible to our last line of defence antibiotics …
of multi-drug resistant bacteria that are not susceptible to our last line of defence antibiotics …
Transferrins and heme-compounds as iron sources for pathogenic bacteria
BR Otto, A Verweij-van Vught… - Critical reviews in …, 1992 - Taylor & Francis
The low concentration of free iron in body fluids creates bacteriostatic conditions for many
microorganisms and is therefore an important defense factor of the body against invading …
microorganisms and is therefore an important defense factor of the body against invading …