An urgent need exists to better understand the transition from short-term opioid use to
unintended prolonged opioid use (UPOU). The purpose of this work is to propose a …

Both chronic pain and prescription opioid abuse are prevalent and exact a high toll on
patients, physicians, and society. Health care professionals must balance aggressive …

Background Evidence has continued to accumulate regarding the potential risks of treating
chronic pain with long-term opioid therapy (LTOT). Clinical practice guidelines now …

Objectives To determine what proportion of a geographically defined population who
receive new opioid prescriptions progresses to episodic or long-term patterns of opioid …

Background Improved understanding of temporal and regional trends may support safe and
effective prescribing of opioids. Objective We describe national, regional, and facility-level …

Background Long-term efficacy of opioids for non-cancer pain is unproven, but risks argue
for cautious prescribing. Few data suggest how long or how much opioid can be prescribed …

The relationships between the initial opioid prescription characteristics and pain etiology
with the probability of opioid discontinuation were explored in this retrospective cohort study …

Objective: Long-term opioid therapy (LTOT) is commonly prescribed for chronic pain, despite
risks such as opioid use disorder (OUD) and overdose. Caring for patients on LTOT can be …

BACKGROUND Primary care clinicians write 45% of all opioid prescriptions in the United
States, but little is known about the characteristics of patients who receive them and the …

Several factors may accelerate opioid discontinuation rates, including lack of information
about the long-term effectiveness of opioids for chronic pain, heightened awareness about …