Background Many genetically multi‐modified donor lines for xenotransplantation have a
background of domestic pigs with rapid body and organ growth. The intrinsic growth …

Xenotransplantation research has made considerable progress in recent years, largely
through the increasing availability of pigs with multiple genetic modifications, effective …

Pig‐to‐human organ transplantation provides an alternative for critical shortage of human
organs worldwide. Genetically modified pigs are promising donors for xenotransplantation …

Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for
transplantation. Means have been identified to overcome hyperacute rejection and acute …

Objective Genetically engineered pigs are thought to be an alternative organ source for
patients in end-stage heart failure unable to receive a timely allograft. However, cardiac …

Background. Orthotopic cardiac xenotransplantation has seen substantial advancement in
the last years and the initiation of a clinical pilot study is close. However, donor organ …

Abstract Purpose of Review The first successful pig to human cardiac xenotransplantation in
January 2022 represented a major step forward in the fields of heart failure, immunology …

The number of donated human organs and tissues for patients with terminal organ failure
falls far short of the need. Alternative sources, such as organs and tissues from animals, are …

Xenotransplantation (cross-species transplantation) using genetically-engineered pig
organs offers a potential solution to address persistent organ shortage. Current evaluation of …

Background Multiple modifications of the porcine genome are required to prevent rejection
after pig-to-primate xenotransplantation. Here, we produced pigs with a knockout of the α1, 3 …