Stability and Hopf bifurcation analysis in a delayed three-node circuit involving interlinked positive and negative feedback loops

G Wang, Z Yang, M Turcotte - Mathematical Biosciences, 2019 - Elsevier
A system involving interlinked positive and negative feedback loops is a flexible motif that
can tune itself in gene regulatory networks. It is well known that time delay is inevitable in …

Stability and bifurcation of delayed bidirectional gene regulatory networks with negative feedback loops

Q Lai - Chinese Journal of Physics, 2018 - Elsevier
This paper studies the stability and bifurcation of three cases of bidirectional gene regulatory
networks with negative feedback loops and time delays. The uniqueness of the positive …

Bifurcation analysis of a mathematical model for genetic regulatory network with time delays

H Zang, T Zhang, Y Zhang - Applied Mathematics and Computation, 2015 - Elsevier
In this paper, we aim to investigate the dynamics of a gene regulatory network which is a
time-delayed version of the model proposed by Elowitz and Leibler [Nature 403 (2000) 335 …

Bifurcation and oscillatory dynamics of delayed cyclic gene networks including small RNAs

M Xiao, WX Zheng, G Jiang - IEEE Transactions on Cybernetics, 2018 - ieeexplore.ieee.org
It has been demonstrated in a large number of experimental results that small RNAs
(sRNAs) play a vital role in gene regulation processes. Thus, the gene regulation process is …

[HTML][HTML] Hopf Bifurcation of a Gene-Protein Network Module with Reaction Diffusion and Delay Effects

SM Ma - International Journal of Modern Nonlinear Theory and …, 2021 - scirp.org
The infinite dimensional partial delay differential equation is set forth and delay difference
state feedback control is considered to describe the cell cycle growth in eukaryotic cell …

Genetic oscillation deduced from Hopf bifurcation in a genetic regulatory network with delays

M Xiao, J Cao - Mathematical biosciences, 2008 - Elsevier
To understand how a gene regulatory network functioning as an oscillator is built, a genetic
regulatory network with two transcriptional delays is investigated. We show by mathematical …

Impacts of multiple time delays on a gene regulatory network mediated by small noncoding RNA

M Liu, F Meng, D Hu - International Journal of Bifurcation and Chaos, 2020 - World Scientific
In this paper, the impacts of multiple time delays on a gene regulatory network mediated by
small noncoding RNA is studied. By analyzing the associated characteristic equation of the …

Dynamic analysis of the time-delayed genetic regulatory network between two auto-regulated and mutually inhibitory genes

G Wang, Z Yang, M Turcotte - Bulletin of Mathematical Biology, 2020 - Springer
Time delays play important roles in genetic regulatory networks. In this paper, a gene
regulatory network model with time delays and mutual inhibition is considered, where time …

Hopf bifurcation analysis for genetic regulatory networks with two delays

T Yu, X Zhang, G Zhang, B Niu - Neurocomputing, 2015 - Elsevier
In this paper, a genetic regulatory network with two time delays is considered. Firstly, the
stabilities with one delay and two delays are investigated. It is shown that the stability …

Stability and bifurcation in a gene regulatory network model with delay

Z Wang, Z Liu, R Yuan - ZAMM‐Journal of Applied …, 2012 - Wiley Online Library
A delayed gene regulatory network model with positive and negative feedbacks is
considered. We investigate the stability of the positive equilibrium and the existence of Hopf …