GPCR heteromers: An overview of their classification, function and physiological relevance
G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …
structures such as homomers and heteromers. Heteromerisation in particular has …
[PDF][PDF] Oligomerization of GPCRs involved in endocrine regulation
G Kleinau, A Müller, H Biebermann - J Mol Endocrinol, 2016 - researchgate.net
More than 800 different human membrane-spanning G-protein-coupled receptors (GPCRs)
serve as signal transducers at biological barriers. These receptors are activated by a wide …
serve as signal transducers at biological barriers. These receptors are activated by a wide …
Impact of G protein-coupled receptor heteromers in endocrine systems
KC Jonas, AC Hanyaloglu - Molecular and Cellular Endocrinology, 2017 - Elsevier
The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated
processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in …
processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in …
History and biological significance of GPCR heteromerization in the neuroendocrine system
G protein-coupled receptors (GPCRs) constitute a large family of seven transmembrane
proteins that regulate major cellular functions. The important role of GPCRs in the …
proteins that regulate major cellular functions. The important role of GPCRs in the …
Contribution of heteromerization to G protein-coupled receptor function
SA Gaitonde, J González-Maeso - Current opinion in pharmacology, 2017 - Elsevier
Highlights•Family A GPCRs can function as monomers but they also form higher order
complexes.•These complexes are involved in almost every step of the GPCR life cycle.•They …
complexes.•These complexes are involved in almost every step of the GPCR life cycle.•They …
G-protein coupled receptor oligomerization in neuroendocrine pathways
KM Kroeger, KDG Pfleger, KA Eidne - Frontiers in Neuroendocrinology, 2003 - Elsevier
Protein–protein interactions are fundamental processes for many biological systems
including those involving the superfamily of G-protein coupled receptors (GPCRs). A …
including those involving the superfamily of G-protein coupled receptors (GPCRs). A …
Probing GPCR dimerization using peptides
Z Farooq, LA Howell, PJ McCormick - Frontiers in Endocrinology, 2022 - frontiersin.org
G protein-coupled receptors (GPCRs) are the largest class of membrane proteins and the
most common and extensively studied pharmacological target. Numerous studies over the …
most common and extensively studied pharmacological target. Numerous studies over the …
Biological significance of GPCR heteromerization in the neuro-endocrine system
Clustering of proteins in higher order complexes is a common theme in biology and
profoundly influences protein function. The idea that seven-transmembrane spanning G …
profoundly influences protein function. The idea that seven-transmembrane spanning G …
Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding …
SN Roed, A Orgaard, R Jorgensen… - Frontiers in …, 2012 - frontiersin.org
The superfamily of the seven transmembrane G-protein-coupled receptors (7TM/GPCRs) is
the largest family of membrane-associated receptors. GPCRs are involved in the …
the largest family of membrane-associated receptors. GPCRs are involved in the …
When simple agonism is not enough: emerging modalities of GPCR ligands
NJ Smith, KA Bennett, G Milligan - Molecular and cellular endocrinology, 2011 - Elsevier
Recent advances in G protein-coupled receptors have challenged traditional definitions of
agonism, antagonism, affinity and efficacy. The discovery of agonist functional selectivity and …
agonism, antagonism, affinity and efficacy. The discovery of agonist functional selectivity and …