Objectives: Treatment guidelines discourage long-term opioid treatment for patients with
chronic pain and major depression, but this treatment occurs commonly, producing higher …

Depression may be a critical factor in the initiation and maintenance of opioids. This study
investigated the association among opioid use, pain, and depression in patients evaluated …

PURPOSE Recent results suggests the risk of a new onset of depression increases with
longer duration of opioid analgesic use. It is unclear whether new-onset depression related …

BACKGROUND: Chronic opioid therapy has increased dramatically, as have complications
related to prescription opioids. Little is known about the problems and concerns attributed to …

OBJECTIVE: We report trends in long-term opioid use among patients with a history of
depression from two large health plans. METHODS: Using claims data, age-and gender …

Depression is associated with receipt of higher doses of prescription opioids. It is not known
whether the reverse association exists in that an increased opioid dose is associated with …

Several studies have shown that chronic opioid analgesic use is associated with increased
risk of new-onset depression. It is not known if patients with remitted depression are at …

Objective: The authors sought to ascertain the relationship between moderate and more
severe pain and prescription opioid use disorders in the noninstitutionalized US population …

ABSTRACT BACKGROUND Prescription opioid analgesic use has quintupled recently.
Evidence linking opioid use with depression emanates from animal models and studies of …

D espite advances in pain management techniques, the patient with chronic pain continues
to represent a clinical chal lenge. Chronic pain encompasses a broad spectrum of …