Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders

RN Ruggiero, MT Rossignoli, DB Marques… - Frontiers in cellular …, 2021 - frontiersin.org
The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …

Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders

Y Goto, CR Yang, S Otani - Biological psychiatry, 2010 - Elsevier
Prefrontal cortex (PFC) mediates an assortment of cognitive functions including working
memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus …

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Z Yan, B Rein - Molecular psychiatry, 2022 - nature.com
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

The role of aberrant neural oscillations in the hippocampal-medial prefrontal cortex circuit in neurodevelopmental and neurological disorders

N Shing, MC Walker, P Chang - Neurobiology of Learning and Memory, 2022 - Elsevier
The hippocampus (HPC) and medial prefrontal cortex (mPFC) have well-established roles in
cognition, emotion, and sensory processing. In recent years, interests have shifted towards …

Hippocampal‐prefrontal circuit and disrupted functional connectivity in psychiatric and neurodegenerative disorders

M Li, C Long, L Yang - BioMed research international, 2015 - Wiley Online Library
In rodents, the hippocampus has been studied extensively as part of a brain system
responsible for learning and memory, and the prefrontal cortex (PFC) participates in …

Impaired functional connectivity in the prefrontal cortex: A mechanism for chronic stress‐induced neuropsychiatric disorders

I Negrón-Oyarzo, F Aboitiz, P Fuentealba - Neural plasticity, 2016 - Wiley Online Library
Chronic stress‐related psychiatric diseases, such as major depression, posttraumatic stress
disorder, and schizophrenia, are characterized by a maladaptive organization of behavioral …

Hippocampal-prefrontal interactions in cognition, behavior and psychiatric disease

T Sigurdsson, S Duvarci - Frontiers in systems neuroscience, 2016 - frontiersin.org
The hippocampus and prefrontal cortex (PFC) have long been known to play a central role
in various behavioral and cognitive functions. More recently, electrophysiological and …

From shortage to surge: a developmental switch in hippocampal–prefrontal coupling in a gene–environment model of neuropsychiatric disorders

H Hartung, N Cichon, V De Feo, S Riemann… - Cerebral …, 2016 - academic.oup.com
Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part
from abnormal communication within hippocampal–prefrontal circuits. While it has been …

[HTML][HTML] The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?

BP Godsil, JP Kiss, M Spedding, TM Jay - European …, 2013 - Elsevier
While the hippocampal formation and the prefrontal cortex each have a well-established role
in cognitive and mnemonic processes, the extent and manner in which these structures …

Subcellular synaptic connectivity of layer 2 pyramidal neurons in the medial prefrontal cortex

JP Little, AG Carter - Journal of Neuroscience, 2012 - Soc Neuroscience
Pyramidal neurons in the prefrontal cortex (PFC) are important for the control of cognitive
and emotional behavior. The medial PFC (mPFC) receives diverse long-range excitatory …