Intracellular pathogens have developed elaborate mechanisms to exploit the different
cellular systems of their unwilling hosts to facilitate their entry, replication, and survival. In …

The actin cytoskeleton and Rho GTP ase signaling to actin assembly are prime targets of
bacterial and viral pathogens, simply because actin is involved in all motile and membrane …

The actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of
entering into non-phagocytic cells, the so-called 'invasive bacteria'. Among them, a few also …

Highlights•Intracellular bacterial pathogens use different strategies for actin-based
motility.•Diverse networks of host and bacterial proteins coordinate motility.•Pathogens also …

Intracellular bacterial pathogens replicate within eukaryotic cells and display unique
adaptations that support key infection events including invasion, replication, immune …

The Arp2/3 complex consists of seven highly conserved and tightly associated subunits, two
of which are the actin-related proteins Arp2 and Arp3. One of the best-studied functions of …

SUMMARY A diverse group of intracellular microorganisms, including Listeria
monocytogenes, Shigella spp., Rickettsia spp., and vaccinia virus, utilize actin-based motility …

Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host
cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting …

Viral infection converts the normal functions of a cell to optimize viral replication and virion
production. One striking observation of this conversion is the reconfiguration and …

The actin-related protein (Arp) 2/3 complex nucleates branched actin filament networks
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …