The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

The human calcium‐sensing receptor (CaSR) is widely expressed in the body, where its
activity is regulated by multiple orthosteric and endogenous allosteric ligands. Each ligand …

In this article we consider the mechanisms by which the calcium-sensing receptor (CaSR)
induces its cellular responses via the control (activation or inhibition) of signaling pathways …

The calcium-sensing receptor (CaSR) is a widely expressed G protein-coupled receptor
(GPCR) that mediates numerous tissue-specific functions. Its multiple ligands and diverse …

Ca2+-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many
(patho) physiological processes by responding to extracellular stimuli, including divalent …

The calcium-sensing receptor (CASR) is expressed in parathyroid hormone (PTH)-secreting
cells of the parathyroid gland and cells lining the renal tubule. The activated CASR …

The extracellular calcium (Ca _ o^ 2+)-sensing receptor (CaSR) was the first GPCR
identified whose principal physiological ligand is an ion, namely extracellular Ca 2+. It …

Drugs that allosterically target the human calcium-sensing receptor (CaSR) have substantial
therapeutic potential, but are currently limited. Given the absence of high-resolution …

After the discovery of molecules modulating G protein-coupled receptors (GPCRs) that are
able to selectively affect one signaling pathway over others for a specific GPCR, thereby …

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor whose function can
be allosterically modulated in a positive or negative manner by calcimimetics or calcilytics …