Animal cell-based expression platforms enable the production of complex biomolecules
such as recombinant proteins and viral vectors. Although most biotherapeutics are produced …

Highlights•Manufacture of biopharmaceuticals, virus-like particles and viral vectors.•System
biology,'omics, cellular phenotype and cell engineering.•Cell line development, culture and …

The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its
ease of growth in serum-free suspension culture and its amenability to transfection, this cell …

Biotherapeutic proteins represent a mainstay of treatment for a multitude of conditions, for
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …

Recombinant Chinese hamster ovary cells (rCHO) cells have been the most commonly used
mammalian host for large-scale commercial production of therapeutic proteins. Recent …

<? xm-replace_text {Heading}?> Abstract Mammalian cell expression systems are the
dominant tool today for producing complex biotherapeutic proteins. In this chapter, we …

The demand for recombinant therapeutic proteins is significantly increasing. There is a
constant need to improve the existing expression systems, and also developing novel …

From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …

The purpose of this review is to describe the current status and to highlight several emerging
trends in the manufacture of recombinant therapeutic proteins in cultivated mammalian cells …

Established animal cells, such as Vero, Madin Darby canine kidney (MDCK) or chicken
embryo fibroblasts (CEFs), are still the main cell lines used for viral vaccine production …