[HTML][HTML] Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS

P Yu, Y Han, L Meng, Y Tian, Z Jin, J Luo, C Han… - … Pharmaceutica Sinica B, 2024 - Elsevier
Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung
metastases, severely impacting patient survival rates. Extracellular vesicles, particularly …

Engineered Exosomes Loaded with miR‐563 Inhibit Lung Cancer Growth

W Gao, N Yang, C Yin, Y Zeng, X Zhu - Journal of oncology, 2022 - Wiley Online Library
The malignancy of lung cancer (LC) is serious in the world. Exosomes are well‐known
natural nanovesicles, which are reported to have the potential to carry functional miRNAs as …

Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer

H Nie, X Xie, D Zhang, Y Zhou, B Li, F Li, F Li, Y Cheng… - Nanoscale, 2020 - pubs.rsc.org
Engineered exosomes have become popular drug delivery carriers for cancer treatment.
This is partially due to the interesting property, ie exosome organotropism, which plays an …

Tumor-derived exosomal linc00881 induces lung fibroblast activation and promotes osteosarcoma lung migration

X Chang, Q Tan, J Xu, X Wu, Y Wang, Y Zhang… - Cancer Cell …, 2023 - Springer
Osteosarcoma (OS) commonly metastasizes to the lung, yet the underlying molecular
mechanisms remain poorly understood. Exosomes play a crucial role in tumor migration …

Exosomal miR-328 originated from pulmonary adenocarcinoma cells enhances osteoclastogenesis via downregulating Nrp-2 expression

C Zhang, J Qin, L Yang, Z Zhu, J Yang, W Su… - Cell Death …, 2022 - nature.com
Osseous metastases of pulmonary carcinoma and the detailed mechanisms remain unclear,
and the effects of exosomes (Exos) originated from pulmonary adenocarcinoma cells in this …

Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer

W Zhou, M Xu, Z Wang, M Yang - Cancer cell international, 2021 - Springer
As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs,
chemotherapeutic drugs, and anti-inflammatory drugs. As a genetic drug carrier, exosomes …

miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer

J Zhou, H Wang, Q Sun, X Liu, Z Wu, X Wang… - … Therapy-Nucleic Acids, 2021 - cell.com
Non-small cell lung cancer (NSCLC) is the most common form of cancer, resulting in cancer-
related deaths worldwide. Exosomes, a subclass of extracellular vesicles, are produced and …

miR-371b-5p-engineered exosomes enhances tumor inhibitory effect

Q Xue, Y Yang, L Yang, X Yan, Z Shen, J Liu… - Frontiers in Cell and …, 2021 - frontiersin.org
Background: Exosomes are well-known natural nanovesicles, that represent one of the
recently discovered modes of intercellular communication due to their ability to transmit …

[HTML][HTML] Exosomes loaded with miR-665 inhibit the progression of osteosarcoma in vivo and in vitro

B Zhang, Y Yang, R Tao, C Yao, Z Zhou… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Objective: Osteosarcoma (OS) is the most common primary malignant bone tumor and has a
poor prognosis. Recent research has suggested that miR-665 affects the progression of OS …

[HTML][HTML] Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

K Zhang, C Dong, M Chen, T Yang, X Wang, Y Gao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Rationale: Extracellular vesicles (EVs) have emerged as novel mediators of cell-to-
cell communication that are capable of the stable transfer of therapeutic microRNAs …