Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

A Parker, S Romano, R Ansorge, A Aboelnour… - Microbiome, 2022 - Springer
Background Altered intestinal microbiota composition in later life is associated with
inflammaging, declining tissue function, and increased susceptibility to age-associated …

Microbiota from young mice counteracts selective age-associated behavioral deficits

M Boehme, KE Guzzetta, TFS Bastiaanssen… - Nature Aging, 2021 - nature.com
The gut microbiota is increasingly recognized as an important regulator of host immunity and
brain health. The aging process yields dramatic alterations in the microbiota, which is linked …

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity-and neurotransmission-related …

A D'Amato, L Di Cesare Mannelli, E Lucarini, AL Man… - Microbiome, 2020 - Springer
Background The gut-brain axis and the intestinal microbiota are emerging as key players in
health and disease. Shifts in intestinal microbiota composition affect a variety of systems; …

Gut microbiota: critical controller and intervention target in brain aging and cognitive impairment

H Li, J Ni, H Qing - Frontiers in aging neuroscience, 2021 - frontiersin.org
The current trend for the rapid growth of the global aging population poses substantial
challenges for society. The human aging process has been demonstrated to be closely …

A review of the preclinical and clinical studies on the role of the gut microbiome in aging and neurodegenerative diseases and its modulation

HM Hashim, S Makpol - Frontiers in cellular neuroscience, 2022 - frontiersin.org
As the world population ages, the burden of age-related health problems grows, creating a
greater demand for new novel interventions for healthy aging. Advancing aging is related to …

The gut microbiota is an emerging target for improving brain health during ageing

M Boehme, KE Guzzetta, C Wasén, LM Cox - Gut microbiome, 2023 - cambridge.org
The gut microbiota plays crucial roles in maintaining the health and homeostasis of its host
throughout lifespan, including through its ability to impact brain function and regulate …

Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome

JD Hoffman, I Parikh, SJ Green, G Chlipala… - Frontiers in Aging …, 2017 - frontiersin.org
Advancing age is the top risk factor for the development of neurodegenerative disorders,
including Alzheimer's disease (AD). However, the contribution of aging processes to AD …

Microbiome-metabolome signatures in mice genetically prone to develop dementia, fed a normal or fatty diet

E Sanguinetti, MC Collado, VG Marrachelli… - Scientific Reports, 2018 - nature.com
Cognitive decline, obesity and gut dysfunction or microbial dysbiosis occur in association.
Our aim was to identify gut microbiota-metabolomics signatures preceding dementia in …

Multi-modal single-cell analysis reveals brain immune landscape plasticity during aging and gut microbiota dysbiosis

SM Golomb, IH Guldner, A Zhao, Q Wang, B Palakurthi… - Cell reports, 2020 - cell.com
Phenotypic and functional plasticity of brain immune cells contribute to brain tissue
homeostasis and disease. Immune cell plasticity is profoundly influenced by tissue …

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

AS Alsegiani, ZA Shah - Neural Regeneration Research, 2022 - journals.lww.com
Recent emerging research on intestinal microbiota and its contribution to the central nervous
system during health and disease has attracted significant attention. Age-related intestinal …