Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including
depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of …

In response to extreme stress, individuals either show resilience or succumb to despair. The
prefrontal cortex (PFC) is required for coping with stress, and PFC dysfunction has been …

The prefrontal cortex (PFC) is highly sensitive to the effects of stress, a known risk factor of
mood disorders including anxiety and depression. Abnormalities in PFC functioning have …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the
onset of mood disorders, such as depression and anxiety, which are more prevalent in …

Depression is an increasingly common but extremely serve mood disorder that remains
poorly understood and inadequately treated. Fast-spiking parvalbumin-positive interneurons …

The prevailing view is that parvalbumin (PV) interneurons play modulatory roles in
emotional response through local medium spiny projection neurons (MSNs). Here, we show …

Stress, a prevalent experience in modern society, is a major risk factor for many psychiatric
disorders. Although sensorimotor abnormalities are often present in these disorders, little is …

Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Psychological stress contributes to the onset and exacerbation of nearly all neuropsychiatric
disorders. Individual differences in stress-regulatory circuits can therefore dramatically affect …