Angiogenesis is important in the growth and progression of solid tumours. The main pro-
angiogenic factor, namely vascular endothelial growth factor (VEGF), also known as …

Angiogenesis is crucial to tumour initiation, survival and metastasis. Vascular endothelial
growth factor (VEGF) is one of the most important pro-angiogenic factors in cancer …

The importance of vascular endothelial growth factor (VEGF) as a regulator of normal and
tumor blood vessel growth has been increasingly characterized over the past two decades …

Inhibiting the angiogenic process is a clever method of cancer care. Over the last decade,
some antiangiogenic compounds have been developed and approved for cancer treatment …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the biology of angiogenesis. Identify the role of VEGF in normal and tumor angiogenesis …

Background: Angiogenesis is essential for cancer growth and metastasis. VEGF is a key
modulator of angiogenesis and its overexpression is correlated with advanced disease and …

When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical
practice more than 15 years ago, it was one of the first targeted therapies and the first …

The existence of factors that stimulate blood vessel growth, thereby recruiting a neovascular
supply to nourish a growing tumour, was postulated many decades ago, although the …

Abstract Bevacizumab (Avastin; Genentech/Roche), an antibody against vascular
endothelial growth factor, was approved by the US FDA in February 2004 for the first-line …

Abstract Bevacizumab (Avastin™, Genentech) is a humanized monoclonal antibody
targeting vascular endothelial growth factor (VEGF), a critical angiogenic factor involved in …