Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis

M Karbalaei, A Mosavat, S Soleimanpour… - Current …, 2024 - Springer
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.
tb) infection. In the present study, a multi-stage M. tb immunodominant Fcγ1 fusion protein …

Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine

A Mosavat, S Soleimanpour, H Farsiani… - Infection, Genetics and …, 2016 - Elsevier
Tuberculosis (TB) remains a major health problem worldwide. Currently, the Bacilli Calmette-
Guérin (BCG) is the only available licensed TB vaccine, which has low efficacy in protection …

Mycobacterium tuberculosis Ag85b: hfcγ1 recombinant fusion protein as a selective receptor-dependent delivery system for antigen presentation

MKZ Babaki, M Taghiabadi, S Soleimanpour… - Microbial …, 2019 - Elsevier
Introducing an effective vaccine for tuberculosis (TB) is an urgent need. Mycobacterium
tuberculosis (Mtb) Ag85 complex is suggested for making protective immunodominant …

Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis

A Kebriaei, M Derakhshan, Z Meshkat… - Molecular biology …, 2016 - Springer
As an ancient disease, tuberculosis (TB) is a major global health threat. Therefore, there is
an urgent need for an effective and safe anti-TB vaccine. In the current study, a delivery …

Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10. 4–HspX

H Niu, L Hu, Q Li, Z Da, B Wang, K Tang, Q Xin, H Yu… - Vaccine, 2011 - Elsevier
To search for more effective vaccines to enhance the immunogenicity and protective efficacy
of Mycobacterium bovis Bacille Calmette-Guerin (BCG) and to control or even eradicate …

Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70

M Tebianian, AZ Hoseini, SM Ebrahimi… - Biologicals, 2011 - Elsevier
Tuberculosis (TB) remains as a major public health problem worldwide. Identification and
selection of immunodominant antigens of Mycobacterium tuberculosis (MTB), capable of …

The development and preliminary evaluation of a new Mycobacterium tuberculosis vaccine comprising Ag85b, HspX and CFP-10:ESAT-6 fusion protein with CpG …

L Chen, M Xu, ZY Wang, BW Chen… - FEMS Immunology & …, 2010 - academic.oup.com
Ag85b and HspX of Mycobacterium tuberculosis (Mtb)(H37Rv) were expressed and purified
in this study. These two proteins were combined with another fusion protein CFP-10: ESAT-6 …

Fusion protein Ag85B-MPT64190–198-Mtb8. 4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium …

Y Luo, B Wang, L Hu, H Yu, Z Da, W Jiang, N Song… - Vaccine, 2009 - Elsevier
Tuberculosis (TB) remains a major infectious disease worldwide despite chemotherapy and
BCG vaccine. The efficacy of the current TB vaccine BCG varies from 0 to 80%. New …

Fc-based delivery system enhances immunogenicity of a tuberculosis subunit vaccine candidate consisting of the ESAT-6: CFP-10 complex

H Farsiani, A Mosavat, S Soleimanpour… - Molecular …, 2016 - pubs.rsc.org
Tuberculosis (TB) remains a major global health threat despite chemotherapy and Bacilli
Calmette–Guérin (BCG) vaccination. Therefore, a safer and more effective vaccine against …

Immunogenicity and Protective Efficacy of a Fusion Protein Vaccine Consisting of Antigen Ag85B and HspX against Mycobacterium tuberculosis Infection in Mice

Q Li, H Yu, Y Zhang, B Wang, W Jiang… - Scandinavian …, 2011 - Wiley Online Library
Subunit vaccines have the potential advantage to boost Mycobacterium bovis Bacillus
Calmette‐Guérin (BCG)‐primed immunity in adults. However, most candidates are antigens …