It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

The recombinant human prostaglandin D2 (PGD2) receptor, hCRTH2, has been expressed
in HEK293 (EBNA) and characterized with respect to radioligand binding and signal …

Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase (s),
which occurred between 1958 and 1976, was followed by a classification system for …

Abstract Comparison of rank orders of agonist potency of the anturally occurring
prostanoids. PGD 2, PGE 2, PGF 2 α and PGI 2 as well as the stable TxA 2 mimetic, U …

Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2α, PGI2,
TxA2, and PGD2. These autacrine lipid mediators interact with specific members of a family …

There is no universally accepted classification of prostanoid receptors. This article reviews
what information there is in the literature, and puts forward a proposal for a general …

Prostanoids are potent oxygenated lipid molecules that contribute to a wide variety of
physiological responses and pathological processes. They are generated by the metabolism …

Stable cell lines that individually express the eight known human prostanoid receptors (EP1,
EP2, EP3, EP4, DP, FP, IP and TP) have been established using human embryonic kidney …

Prostaglandins and thromboxanes are locally acting hormones derived from arachidonic
acid by the actions of cyclooxygenases, and are responsible for a wide variety of …

Prostacyclin (I'GI,) is primarily derived from vascular endothelium and plavs an important
inhibitory role in the local control of va&lar tone and platelet aggregation'. These …