Human pancreatic cholesterol esterase (hCEase) is one of the lipases found to involve in
the digestion of large and broad spectrum of substrates including triglycerides …

Pancreatic cholesterol esterase (CEase) is a serine hydrolase involved in the hydrolysis of
variety of lipids and transport of free cholesterol. In this study, pharmacophore hypotheses …

Primary hypercholesterolemia is the root cause for major health issues like coronary heart
disease and atherosclerosis. Regulating plasma cholesterol level, which is the product of …

Cardiovascular diseases (CVDs) are the leading causes of death, morbidity, and health
expenses in developed and developing countries. Hyperlipidemia is the increase in plasma …

Elevated cholesterol levels are a primary risk factor for the development of coronary artery
disease. Dietary changes associated with drug therapy can reduce high serum cholesterol …

New drug discovery is considered broadly in terms of two kinds of investigational activities
such as exploration and exploitation. This study deals with the evaluation of the cholesterol …

Coronary heart disease is a leading cause of death, and represents an increasing burden
on healthcare resources worldwide. It is one of the most investigated diseases in Medicinal …

In this study, the concept of dynamic combinatorial chemistry (DCC) was applied to explore
novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates …

Hypercholesterolemia is a serious condition that may lead to coronary heart disease, heart
attack and stroke raising the rate of morbidity and mortality in hypocholesterolemic patients …

The angiotensin-converting enzyme (ACE) is a two-domain dipeptidylcarboxypeptidase,
which has a direct involvement in the control of blood pressure by performing the hydrolysis …