Abstract Carboxylesterase 2 (CES2) plays a critical role in the metabolism of ester-and
amide-containing drugs and thus has an impact on drug efficacy and toxicity. This study …

Carboxylesterases in human body play pivotal roles for catalyzing the hydrolysis of
endogenous and exogenous substances such as lipids, thioesters and amides …

Development of new near-infrared fluorophores is one of the eternal themes in the field of
biosensing and biological imaging. In this work, we constructed a novel fluorophore platform …

Abstract Carboxylesterase 2 (CES2) is a serine-type hydrolase that plays important roles in
xenobiotic detoxification and lipid metabolism. Its abnormal expression is highly associated …

Early disease diagnosis is crucial for human health and successful therapy.
Carboxylesterase 2 (CES2), the main enzyme found in many tumor tissues, is closely …

Carboxylesterases (CEs) play great role in CEs-related diseases and drug metabolism.
Selectively monitoring its activity is important to explore its role in CEs-related diseases and …

Carboxylesterases (CESs) are critical for metabolizing ester-containing biomolecules and
are specifically important in liver metabolic disorders. The modulation of CESs is also an …

Carboxylesterase (CE) localized in the lumen of the endoplasmic reticulum (ER) hydrolyzes
many prodrugs to exert therapeutic effect, such as anticoagulant clopidogrel and …

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-
11) in the treatment against colorectal cancer and also has some relationship with the side …

A novel near-infrared (NIR) fluorescent probe CHC-CES1 based on a hemi-cyanine
skeleton for detecting carboxylesterase 1 (CES1) activity was developed. Herein, CHC …