(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of
new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in …

In this study, we present four multilinear regression quantitative structure-activity relationship
(QSAR) models, the first of which tackles the experimental CA IX isozyme inhibitory activities …

In previous work, 14 salen and tetrahydrosalen compounds have been synthesized and
tested in enzyme inhibition assays against cytosolic human carbonic anhydrase isozymes I …

In this study, sixty novel coumarin-monoterpene compounds were synthesized in two series
[thirty-two compounds (12–43) bearing a triazole ring in the first series, and twenty-eight …

A large number of novel secondary sulfonamides based on the open saccharin scaffold
were synthesized and evaluated as selective inhibitors of four different isoforms of human …

A series of sulfonamides containing coumarin moieties had been prepared that showed a
very interesting profile for the inhibition of two human carbonic anhydrase inhibitors. These …

We have carried out the design, synthesis, and evaluation of a small library of 2-
aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and …

Coumarins behave as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
with a mechanism of inhibition distinct from other classes of inhibitors. A series of 7 …

We report here a thorough structure-activity relationship (SAR) with piperazinylureido
sulfamates as inhibitors of human (h) carbonic anhydrase (CA, EC 4.2. 1.1). A SAR …

The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the
development of new inhibitors of these metalloenzymes a hot topic in current Medicinal …