Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …

Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …

Abstract BACKGROUND AND AIMS Collagen is a major component of the extracellular
matrix (ECM) and has an essential role in the onset and progression of fibrosis and chronic …

Background: The puromycin aminonucleoside nephropathy (PAN) model is associated with
proteinuria and matrix accumulation. We tested the hypothesis that renal COL1A1 and …

Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A
hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of …

Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance
between formation and degradation of extracellular matrix proteins. We investigated the …

Urinary peptides gained significant attention as potential biomarkers especially in the
context of kidney and cardiovascular disease. In this manuscript the recent literature since …

BACKGROUND: Hypertension is a common condition worldwide, yet its underlying
mechanisms remain largely unknown. This study aims at identifying urinary peptides …

Chronic kidney disease is characterized by progressive accumulation of extracellular matrix
and scarring, leading to the loss of kidney function. Excess deposition of the collagen family …

Collagen remodeling in normal and pathologic conditions releases numerous collagen
fragments into biological fluids. Although a few collagen fragments have been tested as …