Regulated mRNA turnover is a highly important process, but its mechanism is poorly
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …

Whereas signalling pathways involved in transcriptional control have been studied
extensively, the pathways regulating mRNA turnover remain poorly understood. We are …

In response to T cell activation signals, the half-life of interleukin-2 (IL-2) mRNA is greatly
extended. The cis elements mediating IL-2 mRNA stabilization are located in its 5′ and 3 …

mRNA transcribed from the mouse KC chemokine gene accumulated to significantly higher
levels in multiple cell types after treatment with interleukin 1α (IL-1α) as compared with tumor …

Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …

Stabilization of mRNAs contributes to the strong and rapid induction of genes in the
inflammatory response. The signaling mechanisms involved were investigated using a …

The AT-rich interactive domain-containing protein 5a (Arid5a) plays a critical role in
autoimmunity by regulating the half-life of Interleukin-6 (IL-6) mRNA. However, the signaling …

mRNA silencing and storage play an important role in gene expression under diverse
circumstances, such as throughout early metazoan development and in response to many …

Inflammatory cytokines such as interferon (IFN)-γ, interleukin (IL)-2, tumor-necrosis factor
(TNF)-α and IL-17 play an important role in the pathogenesis of cell-mediated autoimmune …

An important emerging theme is that heterogeneous nuclear ribonucleoproteins (hnRNPs)
not only function in the nucleus but also control the fates of mRNAs in the cytoplasm. Here …