Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Fibrosis results from aberrant wound healing and is characterized by an accumulation of
extracellular matrix, impairing the function of an affected organ. Increased deposition of …

Significance: This review provides current overview of the emerging role of innate immunity
in driving fibrosis, and preventing its resolution, in scleroderma (systemic sclerosis, SSc) …

Macrophages are central orchestrators of the tissue response to injury, with distinct
macrophage activation states playing key roles in fibrosis progression and resolution …

Fibrotic disorders account for an increasing burden of disease-associated morbidity and
mortality worldwide. Although numerous risk factors have been recognized, the etiologies of …

Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …

Inflammation and fibrosis are two inter‐related conditions with many overlapping
mechanisms. Three specific cell types, macrophages, T helper cells, and myofibroblasts …

Abstract Purpose of Review Macrophages are central players in the immune response
following tissue injury. These cells perform many functions, and the changing tissue …

Tissue fibrosis (scarring) is a leading cause of morbidity and mortality. Current treatments for
fibrotic disorders, such as idiopathic pulmonary fibrosis, hepatic fibrosis and systemic …