Initial cyclic‐di‐GMP upregulation triggers sporadic cellular expansion leading to improved cellular survival

Y Yang, S Guo, CJ Hong, ZX Liang… - Biotechnology …, 2024 - Wiley Online Library
Bacterial second messenger c‐di‐GMP upregulation is associated with the transition from
planktonic to sessile microbial lifestyle, inhibiting cellular motility, and virulence. However, in …

Controlling biofilm development through cyclic di-GMP signaling

S Park, K Sauer - Pseudomonas aeruginosa: Biology, Pathogenesis and …, 2022 - Springer
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that
regulates many bacterial behaviors and is of key importance for driving the lifestyle switch …

[HTML][HTML] Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria

M Valentini, A Filloux - Journal of Biological Chemistry, 2016 - ASBMB
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that
regulates many bacterial behaviors and is of key importance for driving the lifestyle switch …

[HTML][HTML] Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

S Lin Chua, Y Liu, Y Li, H Jun Ting, GS Kohli… - Frontiers in cellular …, 2017 - frontiersin.org
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm
life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm …

Tracking the homeostasis of second messenger cyclic-di-GMP in bacteria

A Petchiappan, SY Naik, D Chatterji - Biophysical reviews, 2020 - Springer
Abstract Cyclic-di-GMP (c-di-GMP) is an important second messenger in bacteria which
regulates the bacterial transition from motile to sessile phase and also plays a major role in …

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa

J Düvel, D Bertinetti, S Möller, F Schwede… - Journal of …, 2012 - Elsevier
In many bacteria, high levels of the ubiquitous second messenger c-di-GMP have been
demonstrated to suppress motility and to promote the establishment of surface-adherent …

Bis-(3′-5′)-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

SL Chua, SYY Tan, MT Rybtke, Y Chen… - Antimicrobial agents …, 2013 - Am Soc Microbiol
ABSTRACT Bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) is an intracellular second
messenger that controls the lifestyles of many bacteria. A high intracellular level of c-di-GMP …

[图书][B] Regulatory cascades involving cyclic di-GMP signalling in Pseudomonas aeruginosa

JA Moscoso - 2014 - core.ac.uk
Cyclic di-GMP (c-di-GMP) has emerged as a bacterial second messenger that regulates a
variety of cellular processes, in particular those associated with the switch between a motile …

Targeting c-di-GMP signaling, biofilm formation, and bacterial motility with small molecules

C Opoku-Temeng, HO Sintim - c-di-GMP Signaling: Methods and …, 2017 - Springer
Bacteria possess several signaling molecules that regulate distinct phenotypes. Cyclic di-
GMP (c-di-GMP) has emerged as a ubiquitous second messenger that regulates bacterial …

Establishment of a high-throughput setup for screening small molecules that modulate c-di-GMP signaling in Pseudomonas aeruginosa

KN Rugjee, S An, RP Ryan - JoVE (Journal of Visualized Experiments), 2016 - jove.com
Bacterial resistance to traditional antibiotics has driven research attempts to identify new
drug targets in recently discovered regulatory pathways. Regulatory systems that utilize …