Hypertension: do inflammation and immunity hold the key to solving this epidemic?

MS Madhur, F Elijovich, MR Alexander, A Pitzer… - Circulation …, 2021 - Am Heart Assoc
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Immune and inflammatory mechanisms in hypertension

TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Innate immunity and clinical hypertension

JP Van Beusecum, H Moreno… - Journal of human …, 2022 - nature.com
Emerging evidence has supported a role of inflammation and immunity in the genesis of
hypertension. In humans and experimental models of hypertension, cells of the innate and …

[HTML][HTML] Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

Z Zhang, L Zhao, X Zhou, X Meng, X Zhou - Frontiers in immunology, 2023 - frontiersin.org
Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

Inflammation, immunity, and oxidative stress in hypertension—partners in crime?

IR Barrows, A Ramezani, DS Raj - Advances in chronic kidney disease, 2019 - Elsevier
Hypertension is considered as the most common risk factor for cardiovascular disease.
Inflammatory processes link hypertension and cardiovascular disease, and participate in …

Immune mechanisms in hypertension

A Leibowitz, EL Schiffrin - Current hypertension reports, 2011 - Springer
Inflammation plays an important role in the pathogenesis of hypertension. Innate and
adaptive immune response may contribute to this process. The mechanisms implicating …

Inflammation in hypertension

L Xiao, DG Harrison - Canadian Journal of Cardiology, 2020 - Elsevier
For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …

[HTML][HTML] Immune mechanisms in arterial hypertension. Recent advances

UO Wenzel, H Ehmke, M Bode - Cell and Tissue Research, 2021 - Springer
Increasing evidence indicates that hypertension and hypertensive end-organ damage are
not only mediated by hemodynamic injury. Inflammation also plays an important role in the …

Immunity and hypertension

RM Zhang, KP McNerney, AE Riek… - Acta …, 2021 - Wiley Online Library
Hypertension is the primary cause of cardiovascular mortality. Despite multiple existing
treatments, only half of those with the disease achieve adequate control. Therefore …

Inflammation and hypertension: new understandings and potential therapeutic targets

C De Miguel, NP Rudemiller, JM Abais… - Current hypertension …, 2015 - Springer
Research studying the role of inflammation in hypertension and cardiovascular disease has
flourished in recent years; however, the exact mechanisms by which the activated immune …