Radiation therapy has a fundamental role in the management of cancers. However, despite
a constant improvement in radiotherapy techniques, the issue of radiation-induced side …

Purpose Ionizing radiation is a well-known carcinogen, and epidemiologic efforts have been
made to evaluate cancer risks following a radiation exposure. The basic approach has been …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Background: Cytokines are important for signalling between cells and tissues and constitute
a humoral component of the response of cells and tissues to radiotherapy. Although several …

Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental
irradiation and has been described in many tissues including skin, lung, heart and liver. The …

Inflammation is a homeostatic mechanism aiming to maintain tissue integrity. The underlying
immunological mechanisms and the interrelationship between ionizing radiation and …

Background Radiotherapy is one of the most important therapeutic strategies for treating
cancer. For decades, studies concerning the outcomes of radiotherapy mainly focused on …

Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF),
and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we …