Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

The complement system is an important part of the innate and adaptive immune systems.
Originally characterized as a single serum component contributing to the killing of bacteria …

Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …

The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …

The complement system is best known for its role in innate immunity, providing a first line of
defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Recent studies have indicated that complement proteins might exert novel functions that are
distinct from their well-established inflammatory role, by modulating cellular responses and …

The complement system has long been known to be a major element of innate immunity.
Traditionally, it was regarded as the first line of defense against invading pathogens, leading …

The complement system is a powerful effector arm of innate immunity that typically confers
protection from microbial intruders and accumulating debris. In many clinical situations …