Drug-induced liver injury in older adults

ED Miller, H Abu-Sbeih, NP Chalasani - Geriatric Gastroenterology, 2021 - Springer
The estimated incidence of idiosyncratic drug-induced liver injury (DILI) in the general
population is 13.9 to 19.1 per 100,000 patients per year. Age itself is not a risk factor, but …

Drug-Induced Liver Injury

I Donepudi, H Massoumi, TS Dharmarajan… - Geriatric …, 2012 - Springer
Drug-induced liver injury (DILI) is a common health disorder that is unpredictable and often
poorly understood in pathogenesis. DILI may result in serious, sometimes fatal liver injury in …

Clinical characteristics of drug‐induced liver injury in the elderly

M Onji, S Fujioka, Y Takeuchi, T Takaki… - Hepatology …, 2009 - Wiley Online Library
Aim: The average age of Japanese patients with drug‐induced liver injury (DILI) is expected
to rise as the population ages. The aim of this study was to evaluate the clinical …

Causative Agents, Clinical Features, and Outcomes of Idiosyncratic Drug Induced Liver Injury (DILI) in the Elderly: Results From the DILIN Prospective Study: ACG …

N Chalasani, P Watkins, R Fontana, J Gu… - Official journal of the …, 2012 - journals.lww.com
Purpose: Idiosyncratic drug induced liver injury (DILI) is a rare but serious liver disorder. It is
known to occur in the elderly but the causative agents, clinical characteristics, and outcomes …

Drug-induced liver injury in older people

MI Lucena, J Sanabria, M García-Cortes… - The Lancet …, 2020 - thelancet.com
Drug-induced liver injury (DILI) is a rare, unpredictable, and potentially serious adverse
reaction. It is induced by many drugs, herbs, and dietary supplements and represents a …

An approach to drug-induced liver injury from the geriatric perspective

BT Lee, JA Odin, P Grewal - Current Gastroenterology Reports, 2021 - Springer
Abstract Purpose of Review With its high variability in both presentation and severity, drug-
induced liver injury (DILI) is a complex condition increasingly confronting all providers. DILI …

Risk factors for chronicity in idiosyncratic drug-induced liver injury (DILI): 1054

I Medina-Cáliz, B Garcia-Muñoz, MR Diaz… - Hepatology, 2014 - journals.lww.com
Background: Discontinuation of the causative DILI agent generally leads to liver damage
resolution, except in cases evolving to fulminant hepatic failure or chronicity. We previously …

Clinical characteristics and outcome of drug‐induced liver injury in the older patients: From the young‐old to the oldest‐old

RA Weersink, I Alvarez‐Alvarez… - Clinical …, 2021 - Wiley Online Library
Older patients with hepatotoxicity have been scarcely studied in idiosyncratic drug‐induced
liver injury (DILI) cohorts. We sought the distinctive characteristics of DILI in older patients …

Drug-induced liver injury in the elderly: Consensus statements and recommendations from the IQ-DILI initiative

EB Cohen, M Patwardhan, R Raheja, DH Alpers… - Drug safety, 2024 - Springer
The elderly demographic is the fastest-growing segment of the world's population and is
projected to exceed 1.5 billion people by 2050. With multimorbidity, polypharmacy …

Drug-induced liver injury in older adults

SJ Mitchell, SN Hilmer - Therapeutic Advances in Drug …, 2010 - journals.sagepub.com
Drug-induced liver injury (DILI) is an important cause of hospitalisation and of medication
deregistration. In old age, susceptibility to DILI is affected by changes in physiology and …