Aerobic exercise is associated with decreased cancer incidence and cancer-associated
mortality. However, little is known about the effects of exercise on pancreatic ductal …

Objective: Exercise can produce a large number of cytokines that may benefit cancer
patients, including Interleukin 15 (IL-15). IL-15 is a cytokine that has multiple functions in …

Although successes in cancer immunotherapy have generated considerable excitement, this
form of treatment has been largely ineffective in patients with pancreatic ductal …

Exercise training has been extensively studied in cancer settings as part of prevention or
rehabilitation strategies, yet emerging evidence suggests that exercise training can also …

Pancreatic cancer has an extremely high mortality rate due to its aggressive metastatic
nature. Resolving the underlying mechanisms will be crucial for treatment. Here, we found …

Pharmacologic manipulation of the immune system is emerging as a viable and robust
treatment for some cancer patients. Exercise-induced modulation of the immune system may …

Exercise is associated with favorable changes in circulating immune cells and improved
survival in early-stage breast cancer patients, but the mechansims remain to be fully …

IL-15 is a promising cytokine to expand NK and CD8+ T cells for cancer immunotherapy, but
its application is limited by dose-limiting, on-target off-tumor toxicity. Here, we have …

Abstract Interleukin (IL)-15-N72D superagonist-complexed with IL-15RαSushi-Fc fusion
protein (IL-15SA/IL-15RαSu-Fc; ALT-803) has been reported to exhibit significant anti-tumor …

A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive
stromal and inflammatory reaction. Many efforts have been made to identify the anti-or …