MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases
V Corbo, I Dalai, M Scardoni, S Barbi… - Endocrine-related …, 2010 - erc.bioscientifica.com
Pancreatic endocrine tumors (PETs) may be part of hereditary multiple endocrine neoplasia
type 1 (MEN1) syndrome. While MEN1 gene mutation is the only ascertained genetic …
type 1 (MEN1) syndrome. While MEN1 gene mutation is the only ascertained genetic …
Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to …
B Görtz, J Roth, A Krähenmann, RR de Krijger… - The American journal of …, 1999 - Elsevier
Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically
and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the …
and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the …
Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1
KA Loffler, CA Biondi, M Gartside… - … journal of cancer, 2007 - Wiley Online Library
Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer predisposition syndrome
typified by development of tumors in parathyroid, pituitary and endocrine pancreas, as well …
typified by development of tumors in parathyroid, pituitary and endocrine pancreas, as well …
Pancreatic neuroendocrine neoplasms in multiple endocrine neoplasia type 1
Pancreatic neuroendocrine tumors (pNETs) are a rare group of cancers accounting for about
1–2% of all pancreatic neoplasms. About 10% of pNETs arise within endocrine tumor …
1–2% of all pancreatic neoplasms. About 10% of pNETs arise within endocrine tumor …
Multiple endocrine neoplasia type 1: new clinical and basic findings
DH Schussheim, MC Skarulis, SK Agarwal… - Trends in Endocrinology …, 2001 - cell.com
Multiple endocrine neoplasia type 1 (MEN1) provides a prime example of how a rare
disease can advance our understanding of basic cell biology, neoplasia and common …
disease can advance our understanding of basic cell biology, neoplasia and common …
Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1
HCJ Shen, M He, A Powell, A Adem, D Lorang… - Cancer research, 2009 - AACR
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal syndrome caused by mutations
in the MEN1 tumor suppressor gene. Whereas the protein product of MEN1, menin, is …
in the MEN1 tumor suppressor gene. Whereas the protein product of MEN1, menin, is …
Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain
DK Bartsch, EP Slater, M Albers… - The Journal of …, 2014 - academic.oup.com
Context: Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …
Mutation of the MENIN Gene in Sporadic Pancreatic Endocrine Tumors
EH Wang, SA Ebrahimi, AY Wu, C Kashefi… - Cancer Research, 1998 - AACR
Pancreatic endocrine tumors occur both sporadically and as part of the multiple endocrine
neoplasia type 1 (MEN1) syndrome. MEN1 is an autosomal dominant disease characterized …
neoplasia type 1 (MEN1) syndrome. MEN1 is an autosomal dominant disease characterized …
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues
CA Biondi, MG Gartside, P Waring… - … and cellular biology, 2004 - Am Soc Microbiol
Mutations of the MEN1 gene, encoding the tumor suppressor menin, predispose individuals
to the cancer syndrome multiple endocrine neoplasia type 1, characterized by the …
to the cancer syndrome multiple endocrine neoplasia type 1, characterized by the …
MEN1 gene and its mutations: Basic and clinical implications
T Tsukada, Y Nagamura, N Ohkura - Cancer science, 2009 - Wiley Online Library
Heterozygous germline mutations of the tumor‐suppressor gene MEN1 are responsible for
multiple endocrine neoplasia type 1 (MEN1), a dominantly inherited familial cancer …
multiple endocrine neoplasia type 1 (MEN1), a dominantly inherited familial cancer …